ESTIMATION OF IMMUNOHISTOCHEMICAL EXPRESSION OF CD34 IN NERVOUS SYSTEM TUMOURS
DOI:
https://doi.org/10.52701/monc.2021.v2i2.45Keywords:
CD34, Glioma, immunohistochemestryAbstract
The classification of Central Nervous System (CNS) tumours is constantly changing, due to continuous discoveries in genetic, epigenetic, radiographic and histologic areas that facilitate better classification and subtyping of these heterogenous neoplasms. The tumour development, proliferation and dissemination depend on several factors, such as mitogenic signalling, local microenvironment and angiogenesis. CD34 is a transmembrane glycoprotein, expressed by hematopoietic progenitor/stem cells and also by vascular endothelium and tumour-infiltrating immune cells. The role of CD34 in maintaining vascular integrity has been demonstrated in several solid tumours, therefore it can be used as a marker for tumour vasculature and for vascular pattern characterization within tumours. The aim of our study was to investigate the role of CD34 as angiogenic biomarker that could predict the progression from low to high grade glioma. For this purpose, we evaluated the expression of CD34 in grade I, II, III and IV glioma tissue. We found that all glioma tumours expressed CD34, however, no correlation between histological grade of glioma and CD34 expression or tumour vascularization was observed.
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