• Daniela Miricescu Carol Davila University of Medicine and Pharmacy Bucharest Romania
  • Iulia-Ioana Stanescu-Spinu
  • Alexandra Ripszky Totan
  • Constantin Stefani
  • Silviu Constantin Badoiu
  • Dan Alexandru Enasescu
  • Maria Greabu




hypoxia, solid tumors, isoforms, overexpression, survival rate


Hypoxia can be defined as the master regulator of the tumorigenesis process which can negatively affect the body response to radio- and chemotherapy. Solid tumors are characterized by hypoxia, with O2 concentration around 0.1-1%. Hypoxia-inducible factors, especially HIF-1a are overexpressed in many human pathologies, including various types of cancer, chronic kidney disease, cardiovascular disorders, and age-related macular degeneration. Currently, three isoforms of HIF, HIF-1, HIF-2, and HIF-3 have been identified. HIF-1a is overexpressed in many cancer types, involved in initiation and progression, and correlated with a poor survival rate. The main aim of this review is to present the role of hypoxia during cancer progression.


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