• Andreea Floriana Dinte Faculty of Pharmacy, University of Medicine and Pharmacy of Craiova, Romania
  • Oana Popescu U.M.F. Craiova
  • Daniela Elise Tache Faculty of Medicine, University of Medicine and Pharmacy of Craiova, Romania



vinca alkaloids, cancer, therapies


Because of the lack of cross-resistance with DNA containing drugs and of their distinct mechanism of action, Vinca Alkaloids are already used in combined curative or palliative chemotherapies for over 50 years. They are cytotoxic drugs that act during cellular mitosis, impairing the accelerated growth of cancer cells. Vinca Alkaloids have different chemical structures and the most frequently used are natural derivatives vinblastine and vincristine, but also the semisynthetic products such as vindesine, vinorelbine and vinflunine represent a promising approach for cancer treatment, in spite of their side effects and general toxicities, along with the general concern of the medical world in order to develop new and targeted therapies.


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