THE VINCA ALKALOIDS IN THE ONCOLOGY WORLD
Keywords:vinca alkaloids, cancer, therapies
Because of the lack of cross-resistance with DNA containing drugs and of their distinct mechanism of action, Vinca Alkaloids are already used in combined curative or palliative chemotherapies for over 50 years. They are cytotoxic drugs that act during cellular mitosis, impairing the accelerated growth of cancer cells. Vinca Alkaloids have different chemical structures and the most frequently used are natural derivatives vinblastine and vincristine, but also the semisynthetic products such as vindesine, vinorelbine and vinflunine represent a promising approach for cancer treatment, in spite of their side effects and general toxicities, along with the general concern of the medical world in order to develop new and targeted therapies.
Ciorî?? A, Z?grean-Tuza C, Mo? AC, Carpa R, Pârvu M. The Phytochemical Analysis of Vinca L. Species Leaf Extracts Is Correlated with the Antioxidant, Antibacterial, and Antitumor Effects. Molecules. 2021;26(10):3040. https://doi.org/10.3390/molecules26103040
Rowinsky E. The Vinca Alkaloids. In: Kufe DW, Pollock RE, Weichselbaum RR, et al., editors. Holland-Frei Cancer Medicine. 6th edition. Hamilton (ON): BC Decker; 2003. Available from: https://www.ncbi.nlm.nih.gov/books/NBK12718
Keglevich A, Mayer S, Pápai R, Szigetvári Á, Sánta Z, Dékány M, Szántay C Jr., Keglevich P, Hazai L. Attempted Synthesis of Vinca Alkaloids Condensed with Three-Membered Rings. Molecules. 2018;23(10):2574. https://doi.org/10.3390/molecules23102574
Martino E, Casamassima G, Castiglione S, Cellupica E, Pantalone S, Papagni F, Rui M, Siciliano AM, Collina S. Vinca alkaloids and analogues as anti-cancer agents: Looking back, peering ahead. Bioorganic & medicinal chemistry letters. 2018 Sep 15;28(17):2816-26. https://doi.org/10.1016/j.bmcl.2018.06.044
Bhanot A, Sharma R, Noolvi M. Natural sources as potential anti-cancer agents: A review. International Journal Of Phytomedicine. 2011;3(1):09-26.
Cancer Pain (PDQ®), PDQ Supportive and Palliative Care Editorial Board. PDQ Cancer Information Summaries, Bethesda (MD): National Cancer Institute (US); 2021. Available from:
Merskey H, Bogduk N, eds.: Classification of Chronic Pain: Descriptions of Chronic Pain Syndromes and Definitions of Pain Terms. 2nd ed. IASP Press, 1994. http://www.iasp-pain.org/Education/content.aspx?Item
Davis MP, Walsh D. Epidemiology of cancer pain and factors influencing poor pain control. American Journal of Hospice & Palliative Care. 2004;21:137-42. https://doi.org/10.1177/104990910402100213
Oldenmenger WH, de Raaf PJ, de Klerk C, et al.: Cut points on 0-10 numeric rating scales for symptoms included in the Edmonton Symptom Assessment Scale in cancer patients: a systematic review. Journal of Pain and Symptom Management. 2013;45:1083-93. https://doi.org/10.1016/j.jpainsymman.2012.06.007
Yennurajalingam S, Kang JH, Hui D, et al.: Clinical response to an outpatient palliative care consultation in patients with advanced cancer and cancer pain. Journal of Pain and Symptom Management. 2012;44:340-50. https://doi.org/10.1016/j.jpainsymman.2011.09.014
Rokke PD, Fleming-Ficek S, Siemens NM, Holly JH. Self-efficacy and choice of coping strategies for tolerating acute pain. Journal of Behavioral Medicine. 2004;27:343-60. https://doi.org/10.1023/b:jobm.0000042409.81856.5c
Keefe FJ, Abernethy AP, C Campbell L: Psychological approaches to understanding and treating disease-related pain. Annual Review of Psychology. 2005;56:601-30. https://doi.org/10.1146/annurev.psych.56.091103.070302
Bishop SR, Warr D: Coping, catastrophizing and chronic pain in breast cancer. Journal of Behavioral Medicine. 2003;26:265-81.
Schreiber KL, Martel MO, Shnol H, Shaffer JR, Greco C, Viray N, Taylor LN, McLaughlin M, Brufsky A, Ahrendt G, Bovbjerg D, Edwards RR, Belfer I. Persistent pain in postmastectomy patients: comparison of psychophysical, medical, surgical, and psychosocial characteristics between patients with and without pain. Pain. 2013;154:660-8. https://doi.org/10.1016/j.pain.2012.11.015
Arora RD, Menezes RG. Vinca Alkaloid Toxicity. 2021 Sep 12. In: StatPearls. Treasure Island (FL): StatPearls Publishing; 2021. Available from: https://www.ncbi.nlm.nih.gov/books/NBK557842
Vinca Alkaloids, vinblastine, vincristine, vinorelbine, In: LiverTox, Clinical and Research Information on Drug-Induced Liver Injury, Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases; 2012. Available from:
Alexandru O, Georgescu AM, Dragoi A, Ciurea ME, Taisescu CI, Tataranu LG, Brindusa C, Boldeanu MV, Purcaru SO, Silosi CA, Demetrian A, Dricu A. In vitro Antineoplastic Activity of Dye Compounds on Human Glioblastoma Cells. Revista de Chimie. 2019;70(1):112-17. https://doi.org/10.37358/RC.19.1.6862
T?t?ranu LG, Georgescu AM, Buteic? SA, Silo?i I, Mogo?anu GD, Purcaru ?O, Alexandru O, Stovicek OP, Brîndu?a C, Do?a M, Taisescu CI, Dricu A, Ligustrum vulgare hydroalcoholic extract induces apoptotic cell death in human primary brain tumour cells. Farmacia. 2017;65(5):766-71.
Bates D, Eastman A. Microtubule destabilising agents: far more than just antimitotic anticancer drugs. British Journal of Clinical Pharmacology. 2017;83(2):255-68. https://doi.org/10.1111/bcp.13126
Zhou XJ, Rahmani R. Preclinical and clinical pharmacology of vinca alkaloids. Drugs. 1992;44(4):1-16.
Kamal MA, Al-Zahrani MH, Khan SH, Khan MH, Al-Subhi HA, Kuerban A, Aslam M, Al-Abbasi FA, Anwar F. Tubulin Proteins in Cancer Resistance: A Review. Current Drug Metabolism. 2020;21(3):178-85. https://doi.org/10.2174/1389200221666200226123638
Montag G, Stopper H, Ngo QA, Hintzsche H. The Biological Activity of the Novel Vinca Alkaloids 4-chlorochablastine and 4-chlorochacristine. Current Cancer Drug Targets. 2019;19(3):222-30. https://doi.org/10.2174/1568009618666180430142233
Wouda RM, Miller ME, Chon E, Stein TJ. Clinical effects of vinorelbine administration in the management of various malignant tumor types in dogs: 58 cases (1997-2012). Journal of the American Veterinary Medical Association. 2015;246(11):1230-7.
Zhang D, Kanakkanthara A. Beyond the Paclitaxel and Vinca Alkaloids: Next Generation of Plant-Derived Microtubule-Targeting Agents with Potential Anticancer Activity. Cancer. 2020;12:1721.
Abu Taher M, Abu Bin Nyeem M, Billah M, Ahammed M. Vinca alkaloid- the second most used alkaloid for cancer treatment- A review, International Journal of Physiology, Nutrition and Physical Education. 2017;2(2):723-27
Copyright (c) 2021 Medico Science Press
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
This work by Medico Science Press is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
Medico Oncology is an open access journal which means that all content is freely available without charge to the user or his/her institution. Users are allowed to read, download, copy, distribute or share alike, print, search, or link to the full texts of the articles, or use them for any other lawful purpose, without asking prior permission from the publisher or the author. This is in accordance with the BOAI definition of open access.