• Ani-Simona Sevastre University of Medicine and Pharmacy Craiova
  • Andreea Denisa Hodorog University of Medicine and Pharmacy Craiova



azo-dyes, anticancer, antiproliferative


Azo-dyes are widely used in cosmetic, textile, fibre, leather, printing and painting industries. Besides their colouring function, azo compounds have been reported to have antibacterial, antifungal, antiviral and cytotoxic activities. Mainly, early reports have been linked to azo-dyes as possible causes of mutagenesis and cancer itself. Currently, researchers are studying the azo substances for their medical use in cancer diagnosis and therapy. Dyes have been proved to have antiproliferative effects on cancer cells, by inducing apoptosis and inhibiting receptor tyrosine kinases signalling. Also, some azo-dyes have been demonstrated to inhibit the intracellular signal transduction pathways in vitro. However, the biological impact of azo-dyes, especially in cancer therapy, is still in its beginning, but these properties of azo-dyes open a therapeutic window for cancer treatment. In this review, we will highlight the medical applications of azo-dyes, particularly related to cancer research.



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