CANONICAL AND NONCANONICAL RTKs SIGNALING IN SOLID TUMOURS
Keywords:RTK, canonical, noncanonical, WNT, Hedgehog, Stat3, FGFR, cancer
Tumorigenesis is a multistep process that involves genetic and epigenetic alterations that accumulate over time and give rise to malignant cells. These cells have different attributes than a normal cell and are characterized by uncontrolled proliferation, invasion and resistance to apoptosis. Receptor tyrosine kinases are the target of many alterations that lead to malignant phenotype of the neoplastic cells and to cancer formation. The understanding of their role in cellular processes led to improved therapeutic schemes. Nonetheless, RTKs have intricate pathways that prove to be difficult to comprehend entirely and need further research in order to deliver an efficient therapeutical approach.
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