Acute leukemia and stem cell transplantation


  • Janina Georgiana Goanta Filantropia Hospital. Department of Hematology, Craiova



acute leukemia, stem cell transplantation


Acute leukemias are a type of clonal proliferative malignancies that affect all ages with a predominance of ALL in children and AML in adults. Left untreated they are lethal and require rapid medical management. Not only it imposes high health risks through complications such as infections, but the treatment itself is also a source of potential risks. Acute leukemias require intense medical observation and care. Current treatment consists of a combination of chemotherapeutic agents, stem cell transplantation and supportive care. Recent research offers a better understanding of the pathogenesis of these diseases and provide an advancement in the field of targeted therapeutic agents.


Kayser S, Levis MJ. Advances in targeted therapy for acute myeloid leukaemia. British journal of haematology. 2018;180(4):484-500.

Devine SM, Larson RA. Acute leukemia in adults: recent developments in diagnosis and treatment. CA: a cancer journal for clinicians. 1994;44(6):326-52.

Forestier E, Schmiegelow K. The incidence peaks of the childhood acute leukemias reflect specific cytogenetic aberrations. Journal of pediatric hematology/oncology. 2006;28(8):486-95.

Taga T, Tomizawa D, Takahashi H, Adachi S. Acute myeloid leukemia in children: Current status and future directions. Pediatrics International. 2016;58(2):71-80.

Estey E, Döhner H. Acute myeloid leukaemia. The Lancet. 2006;368(9550):1894-907.

Rashidi A, Weisdorf DJ, Bejanyan N. Treatment of relapsed/refractory acute myeloid leukaemia in adults. British journal of Haematology. 2018;181(1):27-37.

Hasserjian RP, Steensma DP, Graubert TA, Ebert BL. Clonal hematopoiesis and measurable residual disease assessment in acute myeloid leukemia. blood. 2020;135(20):1729-38.

Takami A. Hematopoietic stem cell transplantation for acute myeloid leukemia. International journal of hematology. 2018;107(5):513-8.

Zittoun RA, Mandelli F, Willemze R, De Witte T, Labar B, Resegotti L, et al. Autologous or allogeneic bone marrow transplantation compared with intensive chemotherapy in acute myelogenous leukemia. New England Journal of Medicine. 1995;332(4):217-23.

Pelcovits A, Niroula R. Acute Myeloid leukemia: A review. Rhode Island Medical Journal. 2020;103(3):38-40.

Burnett AK, Goldstone AH, Stevens RM, Hann IM, Rees JK, Gray RG, et al. Randomised comparison of addition of autologous bone-marrow transplantation to intensive chemotherapy for acute myeloid leukaemia in first remission: results of MRC AML 10 trial. The Lancet. 1998;351(9104):700-8.

Medinger M, Lengerke C, Passweg J. Novel therapeutic options in acute myeloid leukemia. Leukemia research reports. 2016;6:39-49.

Ozdemir ZN, Bozda? SC. Graft failure after allogeneic hematopoietic stem cell transplantation. Transfusion and Apheresis Science. 2018;57(2):163-7.

Kassim AA, Savani BN. Hematopoietic stem cell transplantation for acute myeloid leukemia: a review. Hematology/oncology and stem cell therapy. 2017;10(4):245-51.

Kembhavi SA, Somvanshi S, Banavali S, Kurkure P, Arora B. Pictorial essay: Acute neurological complications in children with acute lymphoblastic leukemia. The Indian journal of radiology & imaging. 2012;22(2):98.

Seth R, Singh A. Leukemias in children. The Indian Journal of Pediatrics. 2015;82(9):817-24.

Hallböök H, Gustafsson G, Smedmyr B, Söderhäll S, Heyman M, Group SAALL, et al. Treatment outcome in young adults and children> 10 years of age with acute lymphoblastic leukemia in Sweden: a comparison between a pediatric protocol and an adult protocol. Cancer. 2006;107(7):1551-61.

Jacobsohn DA, Vogelsang GB. Acute graft versus host disease. Orphanet journal of rare diseases. 2007;2(1):1-9.

Couriel D, Caldera H, Champlin R, Komanduri K. Acute graft?versus?host disease: pathophysiology, clinical manifestations, and management. Cancer. 2004;101(9):1936-46.

Babak S, Korzhenkov A, Samarov N, Boichenko E, Goeva M, Voloshina AY, et al. Adverse side effects of anticancer drugs in treatment of children with acute lymphoblastic leukemia. Voprosy onkologii. 2016;62(5):596-605.

Amouzegar A, Dey BR, Spitzer TR. Peripheral Blood or bone marrow stem cells? Practical Considerations in hematopoietic stem cell transplantation. Transfusion medicine reviews. 2019;33(1):43-50.

Lou X, Zhao C, Chen H. Unrelated donor umbilical cord blood transplant versus unrelated hematopoietic stem cell transplant in patients with acute leukemia: A meta-analysis and systematic review. Blood reviews. 2018;32(3):192-202.

Ruggeri A, Sanz G, Bittencourt H, Sanz J, Rambaldi A, Volt F, et al. Comparison of outcomes after single or double cord blood transplantation in adults with acute leukemia using different types of myeloablative conditioning regimen, a retrospective study on behalf of Eurocord and the Acute Leukemia Working Party of EBMT. Leukemia. 2014;28(4):779-86.

Ooi J, Iseki T, Takahashi S, Tomonari A, Takasugi K, Shimohakamada Y, et al. Unrelated cord blood transplantation for adult patients with de novo acute myeloid leukemia. Blood. 2004;103(2):489-91.